Semisolid dosage forms are recommended for the dermal care of babies and children.\nIf we look at the ingredients of these preparations, there are still many cases in which there are\nsubstances (occlusive agents, preservatives) that no longer meet certain requirements of the modern\nage, so it is timely to replace them with other substances. The aim of this work was to formulate a\nscience-based formulation with new components that keep or improve its moisturizing properties,\nrheological parameters, and microbiological stability. Occlusive oils, like white petrolatum and\nliquid paraffn and the preservative parabens are traditional ingredients in oil in water creams, were\nreplaced with white beeswax, sunflower oil, and phenoxyethanol, respectively. Cocoa butter, urea,\nand glycerol were added to improve long-lasting hydration and support the barrier function of the\nreformulated creams. The rheological properties of the formulations were determined. The effects of\nthe preparations on skin hydration and on the barrier function of the skin were tested. Furthermore,\nmicrobiological stability was investigated. The result of the reformulation was an o/w cream that\nprovided a good longer-lasting hydration effect; supported the barrier function of the baby skin\nwithout occlusion; and had adequate consistency, easy spreading, a pleasant skin feeling, proper pH,\nand good microbiological stability.
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